tag:blogger.com,1999:blog-62075324704298898162024-02-07T21:37:17.374-08:00Wellness, netting & NODina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.comBlogger12125tag:blogger.com,1999:blog-6207532470429889816.post-82065881459459696042014-04-28T04:43:00.000-07:002015-02-07T02:07:34.577-08:00Bioactive NO meter was submitted as an idea in the contest - "The best health idea" by Institute of the future.<br />
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<h2 style="margin: 0;">
Bioactive NO meter</h2>
<div style="font-size: 14px; margin: 4px 0;">
NO (Nitric Oxide) is a radical
gas and one of most important signaling molecules in the human body.
Everything one does during ones life e.g., nutrition, physical
activities, relaxation, entertainment, studies etc, is affecting NO
availability. Thus NO measure reflects what is good or bad for us and
what activities to adjust in order to achieve balance, health and
longevity.
An NO meter device (hand meter), which can measure bioactive NO levels
through breath or skin's blood vessel dilation, will enable the user to design
wisely the quality of his life.<br />
Newer <a href="http://www.the-scientist.com/?articles.view/articleNo/38915/title/Light-Lowers-Blood-Pressure/" target="_blank">data show</a> that indeed UVA exposure reduces human blood pressure by releasing nitric oxide metabolites from storage in the skin.<br />
And <a href="http://patents.justia.com/inventor/nathan-stasko" target="_blank">more data on NO and skin</a> such as - Novan Therapeutics is developing a topical nitric-oxide-based burn therapy.<br />
</div>
<div style="margin: 6px 0 14px 0;">
by: Dina Ralt | Jul 31, 2010</div>
<div style="margin: 6px 0;">
<span id="numlikes_99">506</span> people like this. <span class="errmsg" id="status_99" style="diplay: none; margin-left: 10px;"></span></div>
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<a href="http://bodyshockthefuture.org/ideas.php?st=bioactive&reset_pe=1" target="_blank">http://bodyshockthefuture.org/ideas.php?st=bioactive&reset_pe=1</a><br />
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<div class="separator" style="clear: both; text-align: center;">
<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi5u1fCRB_SylKaur-Kd1j6agNOKmi7WlZlGQViH_wmekeuOMA1Fa98A7xt_PVfVU1rFtMpWRAFghaSuVXLAPhyphenhyphenQ0EE9J3VdGN_dqlulLajHSFv2BhFQLtznWKqklZhThmT5Ay6moAVyv8/s1600/NO-meter-RALT.jpg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi5u1fCRB_SylKaur-Kd1j6agNOKmi7WlZlGQViH_wmekeuOMA1Fa98A7xt_PVfVU1rFtMpWRAFghaSuVXLAPhyphenhyphenQ0EE9J3VdGN_dqlulLajHSFv2BhFQLtznWKqklZhThmT5Ay6moAVyv8/s1600/NO-meter-RALT.jpg" height="320" width="267" /></a></div>
<br />Dina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.com8tag:blogger.com,1999:blog-6207532470429889816.post-78996357177286772692012-03-27T03:28:00.000-07:002012-09-13T05:33:03.530-07:00Three days of vegetarianism, experimenting via social nets<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiPMXIKmasgnL_eVljhw3T2lnyDVdiCqid7NVeQdaW0AGWBioEzNqb3pBKoKbtkkP_gpo2yZ_kDzrEXkGrrmHoBJlu30rRvmkdr6k4q1iIn6cmicexLIqMOQaW6htMIwLUwI3OoHvfL4Ik/s1600/saladsP.jpg"><img alt="" border="0" id="BLOGGER_PHOTO_ID_5616910509268856994" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiPMXIKmasgnL_eVljhw3T2lnyDVdiCqid7NVeQdaW0AGWBioEzNqb3pBKoKbtkkP_gpo2yZ_kDzrEXkGrrmHoBJlu30rRvmkdr6k4q1iIn6cmicexLIqMOQaW6htMIwLUwI3OoHvfL4Ik/s320/saladsP.jpg" style="cursor: hand; float: left; height: 168px; margin: 0px 10px 10px 0px; width: 172px;" /></a><br />
The initial topic that we in <a href="http://nettingno.blogspot.com/2009/10/camoni-smart-social-health-website.html">CAMONI</a> want to socially study is how the protein content in the diet affects type 2 diabetes? And is vegan diet relevant to this question?<br />
<br />
The currently available literature indicates that vegetarian and vegan diets present potential <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671114/?tool=pubmed">advantages for the management of type 2 diabetes</a>. Moreover, increased conformity to <a href="http://www.ncbi.nlm.nih.gov/pubmed/19386029?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">vegetarian diets protected against </a>risk of type 2 diabetes even after lifestyle characteristics and BMI were taken into account.<br />
Is it because the vegan diet does not contain animal protein? or maybe it's because on average vegan diets contain less protein?<br />
<br />
It is the beneficial effects of gastric bypass surgery (GBP) to the diabetic that have led me to this suggestion, as this surgery reduces immediately the protein consumption.<br />
<br />
As the incidence of obesity-induced type 2 diabetes continues to increase worldwide, medical studies indicate that surgery to reduce obesity can almost completely eliminate all manifestations of diabetes.<br />
However please note that glycemic control <a href="http://stm.sciencemag.org/content/3/80/80re2.abstract">is improved more after gastric bypass surgery than after equivalent diet-induced weight </a>loss in patients with morbid obesity and type 2 diabetes mellitus.<br />
<br />
What is the mechanism of this better metabolic response after GBP?<br />
<br />
Several studies suggest that it might be related to the presence of amino acids (the bricks of proteins), e.g.<br />
- Branched-chain <a href="http://stm.sciencemag.org/content/3/80/80re2.abstract">amino acids decreased after GBP</a>, but not after dietary intervention<br />
- Five branched-chain and aromatic amino acids had highly significant <a href="http://www.nature.com/nm/journal/v17/n4/abs/nm.2307.html">associations with future diabetes</a>.<br />
<br />
As diets <a href="http://care.diabetesjournals.org/content/33/1/43">high in animal protein are associated with an increased diabetes </a>risk, it is suggested that consumption of energy from protein at the expense of energy from either carbohydrates or fat may similarly increase diabetes risk.<br />
<br />
All these findings indicate that accounting for protein content in dietary recommendations for diabetes prevention may be useful.<br />
<br />
This is the reasoning for our social net study - If your are diabetic Type 2 and care to try, please become vegetarian for 3 days and measure how it affects your sugar levels.<br />
Please comment here or at <a href="http://www.facebook.com/profile.php?id=100001480995049#!/pages/Camoni-Social-health-learning/212284838809104?sk=wall">facebook</a> how it affected you.<br />
<br />
We plan to collect data from many net surfers and see if preliminary conclusions can be deduced. If we trace protein level diabetic effects, it will be interesting to see if we all (men/women, young/old, lean/obese) respond similarly.<br />
<br />
<b>IMPORTANT</b> - For a vegan diet please eliminate for 3 days all animal proteins (eggs, meat, fish, milk and its products) and <a href="http://www.webmd.com/diet/healthtool-food-calorie-counter">replace it with equal calories</a> from nuts, almonds legume or beans (do not add - bread, sugar or sweets).<br />
Please be carefull to <a href="http://diabetes.niddk.nih.gov/dm/pubs/hypoglycemia/">avoid hypoglycemia</a>.<br />
Do not forget to make sure that your physician acknowledges your selected diet.Dina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.com0tag:blogger.com,1999:blog-6207532470429889816.post-62467086085795923032010-04-29T08:16:00.000-07:002011-01-02T22:41:20.506-08:00No milk today...<p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">It’s about a year now that I abstain from milk and milk products. As it has affected (positively) my wellbeing so dramatically, I strongly recommend to generalize the concept - It is worthwhile to search ones roadblocks for health, in situations where ones efforts to heal do not result</span><span class="Apple-style-span" style="font-size:small;"><span dir="rtl"></span></span><span dir="rtl"><span class="Apple-style-span" style="font-size:small;"><span dir="rtl"></span> </span></span><span class="Apple-style-span" style="font-size:small;">in contentment.</span></span></p><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">Losing weight is my personal issue of life (also my </span></span><a href="http://www.biomedcentral.com/1471-2431/6/33"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">scientific field of study</span></span></a><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">), so for years I eat “right” as well as smartly exercise daily, and yet it was milk abstinence that enabled the </span><span style="FONT-WEIGHT: bold" class="Apple-style-span"><span class="Apple-style-span" style="font-size:small;">17kg</span></span><span class="Apple-style-span" style="font-size:small;"> weight loss this year. In the chart below (my "excess kg") you may see that in the previous year I have lost 5 kg with the same exercise & diet but with milk and its products (cottage cheese and yogurts). So milk abstinence enabled over 3 times faster weight loss. Pls note that the no-milk diet is not poorer in calories as instead I eat a lot of almonds which have higher caloric value.</span></span></p><img style="MARGIN: 0px 10px 10px 0px; WIDTH: 232px; FLOAT: left; HEIGHT: 212px; CURSOR: hand" id="BLOGGER_PHOTO_ID_5330334114295686114" border="0" alt="" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgee6gSB9CDnPGjf2_1ZpCwlGOM9CC0mnNiiShkUdCS2GqGQPjqBDrNBaBgrazA3NwjxVa94kUTuAvw6m0JsCm1UNjlJXlfQakMKZVlO_waRsKyf4G4kEFNL0jCNdPUwhbndA19gAsOEpA/s320/graf2.jpg" /> <p class="MsoNoSpacing">It has also (even before the weight loss was manifested) balanced my morning blood sugar levels (I am diabetic II) and now my HbA1c is balanced - 5.6 (it used to be 6.8 regardless of my very low carbohydrates consumption).<br /></p><br /><br /><br /><br /><br /><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">One of my articles on obesity, defines </span></span><a href="http://nettingno.blogspot.com/2008/03/two-urges-to-eat.html"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">2 urges to eat</span></span></a><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;"> - the need to eat as well as satiety, are regulated by these </span><strong><span style="mso-bidi-theme-font: major-bidi; mso-ascii-: major-bidi"><span class="Apple-style-span" style="font-size:small;">two unrelated urges</span></span></strong><span class="Apple-style-span" style="font-size:small;">. One urge is activated by our daily energy expenditure and the other by the need to accumulate energy for the future (activated by the degree of our bodily worry). I have also explained how satiety of the second urge is critical for a healthy weight loss. A </span></span><a href="http://news.bbc.co.uk/2/hi/health/7669966.stm"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">US </span></span></a><a href="http://news.bbc.co.uk/2/hi/health/7669966.stm"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">team indeed found</span></span></a><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;"> levels of white blood cells were highest in men who were unfit and overweight. High levels of white blood cells can be a sign of inflammation/body worry.</span></span><br /><br /><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">Indeed I’ve found that I show </span></span><a href="http://digestive.niddk.nih.gov/ddiseases/pubs/lactoseintolerance/"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">Lactose Intolerance</span></span></a><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;"> and I guess this was a main body-worry which inhibited my health as well as my weight loss. It is intersting to note that in the <a href="http://www.eshg.org/eshg2009/">ESHG 2009 </a>meeting, a study demonstarted <span style="LINE-HEIGHT: 14px;font-family:Tahoma;" class="Apple-style-span" ><span class="Apple-style-span" style="font-size:small;">that the variant responsible for lactose intolerance among Europeans </span><a href="http://scienceblogs.com/gnxp/2009/05/lactase_persistence_correlates.php"><span class="Apple-style-span" style="font-size:small;">was also associated with higher BMI</span></a><span class="Apple-style-span" style="font-size:small;">.</span></span></span></span></p><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">But milk is not the only generator of worry, e.g. </span><span lang="EN"><span class="Apple-style-span" style="font-size:small;">e</span><a href="http://news.msu.edu/story/6081/"><span class="Apple-style-span" style="font-size:small;">xposure to insecticide</span></a><span class="Apple-style-span" style="font-size:small;"> may cause such a worry and thus can play role in obesity… as well as </span><a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17520034"><span class="Apple-style-span" style="font-size:small;">other </span></a></span></span><a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17520034"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">chemical exposures</span></span></a><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">.</span></span></p><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">Milk damage might not be related only to Lactose Intolerance, e.g. it was shown to be related to cancer progress via its </span><span style="color:black;"><a href="http://www.sciencedaily.com/releases/2008/11/081113181428.htm"><span class="Apple-style-span" style="font-size:small;">N-glycolylneuraminic acid</span></a><span class="Apple-style-span" style="font-size:small;">.</span></span></span></p><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">And more:</span></span></p><p class="MsoNoSpacing"><span class="Apple-style-span" style="font-size:small;"><span style="mso-spacerun: yes"></span></span><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">1- French study demonstrated increases in weight with high dairy calcium intakes</span><sup><span class="Apple-style-span" style="font-size:small;"> </span></sup><span class="Apple-style-span" style="font-size:small;">in normal-weight women, and positive</span><sup><span class="Apple-style-span" style="font-size:small;"> </span></sup><span class="Apple-style-span" style="font-size:small;">relations between milk consumption and waist</span><sup><span class="Apple-style-span" style="font-size:small;"> </span></sup><span class="Apple-style-span" style="font-size:small;">circumference change</span><sup><span class="Apple-style-span" style="font-size:small;"> </span></sup><span class="Apple-style-span" style="font-size:small;">in overweight women.</span></span></p><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;"><a href="http://www.ajcn.org/cgi/content/abstract/88/5/1248?etoc">Am. J. Clinical Nutrition, 2008; 88(5), 1248-1255</a></span></span></p><p><span style="font-size:85%;"></span></p><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">2- Milk products appear insulinotropic.</span></span></p><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;"><a href="http://www.ajcn.org/cgi/content/full/74/1/96">Am. J. Clinical Nutrition, 2001; 74(1), 96-100</a></span></span></p><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">3- High intake of various food groups such as red meat, fried potatoes, cheese, and cottage cheese is associated with risk of type 2 diabetes.</span></span></p><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;"><a href="http://care.diabetesjournals.org/cgi/content/short/32/2/263?rss=1">Diabetes Care, 2009, 32, 263-268</a></span></span></p><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">4- In kids (age 9-14), dietary calcium and skim and 1% </span><strong><span style="BACKGROUND: white; mso-bidi-theme-font: major-bidi; mso-ascii-: major-bidi"><span style="FONT-WEIGHT: normal" class="Apple-style-span"><span class="Apple-style-span" style="font-size:small;">milk</span></span></span></strong><span class="Apple-style-span" style="font-size:small;"> were</span><sup><span class="Apple-style-span" style="font-size:small;"> </span></sup><span class="Apple-style-span" style="font-size:small;">associated with weight gain, but dairy fat was not.<br /></span></span><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;"><a href="http://archpedi.ama-assn.org/cgi/content/abstract/159/6/543?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=milk&searchid=1118230750820_276&stored_search=&FIRSTINDEX=0&journalcode=archpedi" target="_blank">Arch Pediatr Adolesc Med. 2005;159:543-550</a></span></span></p><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">5- Children in Crete with insulin-dependent diabetes mellitus, consumed more dairy products and less meats and cereals.<br /></span></span><a href="http://www.ncbi.nlm.nih.gov/pubmed/18714148?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum" target="_blank"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">Ann Nutr Metab. 2008 Aug 19;52(4):308-314</span></span></a><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;"><br /></span></span></p><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;"><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">6- The majority of current evidence from clinical trials does not support the hypothesis that dairy consumption aids in weight or fat loss.</span></span></p><p class="MsoNoSpacing"></p><p dir="rtl" class="MsoNormal"><span style="mso-ansi-language: EN;font-family:'Tahoma','sans-serif';color:black;" dir="ltr" lang="EN" ><span style="font-size:85%;"><a href="http://www3.interscience.wiley.com/journal/119394887/abstract?CRETRY=1&SRETRY=0">Nutrition Reviews, 2008, 66(5),272-297<?xml:namespace prefix = o /><o:p></o:p></a></span></span></p><p></p><p class="MsoNoSpacing"><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">7- A family diet rich in dairy products during childhood<sup> </sup>is associated with a greater risk of colorectal cancer in adulthood.</span></span></p><p class="MsoNoSpacing"></p><p style="TEXT-ALIGN: left; unicode-bidi: embed; DIRECTION: rtl" dir="rtl" class="MsoNoSpacing"><a href="http://www.ajcn.org/cgi/content/abstract/86/6/1722?etoc"><span dir="ltr" style="font-family:'Tahoma','sans-serif';font-size:85%;">Am. J. Clinical Nutrition, 2007, 86(6), 1722-1729</span></a></p>8- The intake of dairy<sup> </sup>products may be associated with an increased risk of prostate<sup> </sup>cancer. <p class="MsoNormal"><span class="apple-style-span"><span style="font-family:'Tahoma','sans-serif';color:#333333;"><a href="http://www.ajcn.org/cgi/content/abstract/81/5/1147">Am. J. Clinical Nutrition, 2005; 81(5), 1147-1154</a><o:p></o:p></span></span></p><p class="MsoNormal"><a href="http://cebp.aacrjournals.org/cgi/content/abstract/17/4/930">Cancer Epidemiol Biomarkers Prev 2008;17(4):930–7<span class="apple-style-span"><span style="font-family:'Tahoma','sans-serif';color:#333333;"><o:p></o:p></span></span></a></p><p class="MsoNormal">9- Milk-the promoter of chronic Western diseases</p><p class="MsoNormal"><a href="http://www.ncbi.nlm.nih.gov/pubmed/19232475">Med Hypotheses. 2009, 72(6), 631-639</a></p><p class="MsoNormal">10- Cow's-Milk-Free Diet as a Therapeutic Option in Childhood Chronic Constipation.</p><p class="MsoNormal"><a href="http://www.ncbi.nlm.nih.gov/pubmed/20453672">J. Pediatr. Gastroenterol. Nutr. 2010, May 4 e-pub ahead of print</a></p><p class="MsoNormal"></p><p></span></span><span style="font-size:0;"><span class="Apple-style-span" style="font-size:small;">and last, </span><span style="color:black;"><span class="Apple-style-span" style="font-size:small;">milk may also </span><a href="http://www.eurekalert.org/pub_releases/2008-09/sfgm-mmh090508.php"><span class="Apple-style-span" style="font-size:small;">help bacteria survive against low levels of antibiotics</span></a>.</span></span></p><p><span style="font-size:0;"><span style="color:black;"><span class="Apple-style-span" style="font-size:small;">It is worth a trial to avoid milk consumption …</span><o:p></o:p></span></span> </p><p>Did you ever try the<a href="http://www.thepaleodiet.com/"> Paleo diet</a>? </p>Dina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.com2tag:blogger.com,1999:blog-6207532470429889816.post-26516407232122403572010-01-29T06:13:00.000-08:002012-11-02T23:36:55.051-07:00Chinese 5 Elements Mark Johnson's Questionnaire<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgR7lTYLu9fdkEbg6RdLASD92UVlzsXWYR7pa9s1_dLvd8kMi5-UGx3Q0iobM3UqBfDENqiBmuRZyWCQEVBsonhoNbaAazVxlttj8ngcgYl07_d4HOdVryCeqcwQW2vdzvcMvePNagtXKU/s1600/flowers6.jpg"><img alt="" border="0" id="BLOGGER_PHOTO_ID_5703059420053585298" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgR7lTYLu9fdkEbg6RdLASD92UVlzsXWYR7pa9s1_dLvd8kMi5-UGx3Q0iobM3UqBfDENqiBmuRZyWCQEVBsonhoNbaAazVxlttj8ngcgYl07_d4HOdVryCeqcwQW2vdzvcMvePNagtXKU/s320/flowers6.jpg" style="cursor: hand; float: left; height: 120px; margin: 0px 10px 10px 0px; width: 180px;" /></a><br />
If the question sounds a lot like you, put +2<br />
If it is somewhat like you, put +1<br />
Put a 0 if it is neutral<br />
-1 if it is not much like you<br />
-2 if it is nothing like you<br />
<br />
<br />
<span style="font-size: 85%;">If you hate questionnaires and refuse to do it, you are more than likely a "Wood" person!</span><br />
<br />
<b>Phase I</b>Are you a natural born initiator?<br />
Do you have problems with authority figures?<br />
Do you suffer from migratory pains?<br />
Do you act assertively and confidently?<br />
Does other people's slowness and clumsiness irritate you?<br />
Do you like struggling against great odds to prove to others you can do it?<br />
Are you frequently doing something or going somewhere?<br />
Do you have high blood pressure?<br />
Have you often been told you don't compromise much?<br />
Do you have to be the first and best?<br />
Does confinement and sitting quietly drive you crazy?<br />
Do you get frequent muscle cramps?<br />
Do you like to make the rules and then break them?<br />
Are you passionate about everything you do?<br />
Do you pioneer new trails wherever you go?<br />
Do your nails alternate between hard and thick and dry and brittle?<br />
Are you impatient with uncommitted people with no direction?<br />
Are you afraid to show vulnerability?<br />
Have you ever had tendonitis?<br />
Do you love speed and adventure?<br />
Do you tend to manipulate people and situations to get what you want?<br />
Is controlling your anger one of your biggest problems?<br />
Do you find any kind of restraint insufferable?<br />
Do you do your best work under pressure?<br />
<br />
<br />
<b>Phase II</b><br />
Would you describe yourself as an introspective "loner"?<br />
Do you have an exaggerated sex drive?<br />
Is the search for TRUTH a prime motivator in your life?<br />
Do you hate superficiality in people?<br />
Are you creative, imaginative and original?<br />
Are you modest and fear being in the limelight?<br />
Are you self contained and self sufficient?<br />
Is deterioration of teeth and gums a problem?<br />
Do you seek the deep mystery in everything?<br />
Are you out of touch with your emotions?<br />
Do you suffer with backaches frequently?<br />
Are you tactless and even rude occasionally?<br />
Do you have a very penetrating and critical mind?<br />
Do you hate waste and conserve everything?<br />
Is stick-to-ativeness one of your strongest virtues?<br />
Do you have hardening of the arteries?<br />
Is it hard for you to share with others?<br />
Do you suffer with isolation and loneliness?<br />
Are you afraid of loosing yourself in others?<br />
Are you considered enigmatic and eccentric by your friends?<br />
Do you have remarkable powers of concentration?<br />
Are you awkward in social circumstances?<br />
Do you have trouble conforming?<br />
Have you had kidney or bladder problems?<br />
Are you watchful and objective with other people?<br />
<br />
<br />
<b>Phase III</b><br />
Do you spend a lot of time and energy consciously seeking the divine?<br />
Do you have an enlarged or weak heart?<br />
Are you charismatic?<br />
Do you have an extreme aversion to pain?<br />
Do you love drama, performing and being in the limelight?<br />
Are you often spontaneous?<br />
Do you get sores on your tongue and around your mouth?<br />
Can't say NO to anyone?<br />
Do you tend to be more sensual than your friends?<br />
Do you love to give your opinion?<br />
Do you fear separation above all else?<br />
Are you clever on your feet?<br />
Do you desire fulfillment more than almost anything?<br />
Do you bore easily with the dull and ordinary?<br />
Do your cheeks turn red easily?<br />
Could you be described as extravagant?<br />
Are you bright and scintillating at social gatherings?<br />
Do you have eczema?<br />
Do you have trouble with boundaries?<br />
Is the need for intimacy a strong motivation with you?<br />
Does sharing come easily?<br />
Are you mostly optimistic and enthusiastic about life?<br />
Are you strongly empathetic?<br />
Do you suffer from anxiety and insomnia?<br />
<br />
<br />
<b>PHASE IV</b>Are you a "law and order' person?<br />
Do you hold righteousness and virtue in high regard?<br />
Are rituals important to you?<br />
Do you have stiff joints and muscles?<br />
Is chaos your enemy?<br />
Do you have no time for nonsense?<br />
Do you hold very precise standards?<br />
Are you really sensitive to temperature changes?<br />
Are you intolerant of disorder and dissonance?<br />
Is your skin and hair really dry?<br />
Do you fear intimacy?<br />
Do you have a strong aesthetic sense?<br />
Does carelessness in others drive you up a wall?<br />
Are you considered cool, dispassionate and distant?<br />
Do you have a tight chest with dry coughing?<br />
Are reason and high principles your guiding light?<br />
Are you a little too strict and nit-picky?<br />
Do you have refined tastes?<br />
Have you been called self-righteous?<br />
Do you have a lot of moles and warts?<br />
Is social involvement on the bottom of your list of important things to do?<br />
Do you have sinus problems?<br />
Does your constant self control drive your spontaneous friends crazy?<br />
Are you into changing other people?<br />
Do you suffer from constipation?<br />
<br />
<br />
<b>PHASE V</b>Do you see yourself as a service oriented person?<br />
Are you working on being more self-reliant?<br />
Do your friends often use you as a negotiator?<br />
Is bloating and water retention a problem?<br />
Do you struggle with inertia and feel "stuck" sometimes?<br />
Does nurturing come easy to you?<br />
Are you haunted with self-doubt?<br />
Do you like to be in charge, but not in the limelight?<br />
Does your efficiency leave something to be desired?<br />
Does your need to be accommodating result in conformity?<br />
Do you often go through an identity crisis?<br />
Is a need to belong strong in you?<br />
Do you suffer with muscle tenderness?<br />
Are you referred to as a "peacemaker" by your friends?<br />
Do you regard loyalty as being one of the more important traits in a person?<br />
Are you quite conservative in your thinking?<br />
Do you have a strong need to be needed?<br />
Are you often involved in everybody else's business?<br />
Do you suffer with swollen glands and other lymphatic disorders?<br />
Would you like things more predictable because things are changing too fast?<br />
Do you tend to be overly protective?<br />
Do unrealistic expectations leave you disappointed much of the time?<br />
Do you try to be all things to all people?<br />
Is there a deep "emptiness" in the pit of your stomach?<br />
Do you have a squarish, solid physique?<br />
<br />
__________________________<br />
<br />
<b>Phase I is the WOOD phase<br />Phase II is the WATER phase<br />Phase III is the FIRE phase<br />Phase IV is the METAL phase<br />Phase V is the EARTH phase</b><br />
<br />
Now add up each phase by subtracting the negatives from the positives and<br />
see which ones have the highest numbers. Often you will have a phase or<br />
phases that are negative. This is OK. The phase with the least amount of<br />
negatives is your dominant phase. We are all a mixture of these phases so<br />
it is the PROPORTION between them that is important. More than 25 points<br />
between the highest and lowest is a sign of imbalance.<br />
<br />
For instance from dominant to weak might look like this...<br />
WOOD +18, FIRE +9, EARTH -9, METAL -10, WATER +5 This is a WOOD person<br />
with a weak EARTH phase. To balance them, strengthen Fire<br />
or...WOOD -25, FIRE -16, EARTH -13, METAL 0, WATER -9, This is a METAL<br />
person with a week WOOD phase. To help them, strengthen their WATER.<br />
or...WOOD +6, FIRE +4, EARTH +1, METAL -1, WATER -2, This person is<br />
balanced and all they need do is maintain that balance!Dina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.com2tag:blogger.com,1999:blog-6207532470429889816.post-78763375411741578292009-10-07T06:32:00.000-07:002011-06-25T01:50:06.023-07:00CAMONI - a smart social health websiteHealth, is a private issue as well as a collective circumstance, thus network phenomena appear to be relevant to health upkeep. This was well established in evaluating smoking cessation (<a href="http://content.nejm.org/cgi/content/abstract/358/21/2249">1</a>) obesity spread (<a href="http://content.nejm.org/cgi/content/abstract/357/4/370">2</a>) as well as happiness expansion (<a href="http://www.bmj.com/cgi/content/abstract/337/dec04_2/a2338">3</a>).<br />Along with its social benefit, the net is an intelligent source of information, which is essential for medical issues in health websites that must be trusted.<br />Information is needed as even minimum medical knowledge is dramatically lacking (<a href="http://www.biomedcentral.com/1741-7015/5/14">4</a>). For example, a community-wide study in New York found that nearly 28 percent of all visits to the pediatric emergency department could have been replaced with a more cost-effective Internet doctor's "visit" (<a href="http://www.sciencedaily.com/releases/2008/05/080506074451.htm">5</a>). It is interesting to note that nowadays, patients doubt doctors' advice when it conflicts with online info (<a href="http://www.ihealthbeat.org/articles/2008/7/30/Patients-Doubt-Doctors-Advice-When-It-Conflicts-With-Online-Info.aspx?topicID=55">6</a>).<br /><br />So what’s the hindrance? Despite the clarity of its essentiality, social health websites evolve much slower than popular social sites. We assume that the prevention is partly due to the required novel attitude/approach in health management. Novel not only to the patients but also to the physicians and caretakers.<br /><br />These considerations were in the root of designing <a href="http://camoni.xnet.co.il/index.php?idr=400&p=921">Camoni</a>, the first Israeli health and medical social network (in Hebrew).<br />The <a href="http://camoni.xnet.co.il/index.php?idr=400&p=921">Camoni</a> (means in Hebrew: “like me”) project was initiated by Prof. M Shani, and its main focus is the wellness of the person with chronic ailment as well as his environment.<br />The disorders that Camoni targets initially include heart failure, diabetes, blood pressure disorders, kidney disorders, obesity, eating disorders, spinal cord injuries, and chronic pain.<br /><br />The Camoni website supplies both medical expertise (knowledge) and communication routes. To establish the trust of the Israeli surfer, Camoni offers the web-surfer, leading Israeli medical experts in chronic diseases. All of the experts are well known and are members of leading hospitals and medical institutes throughout Israel. In joining Camoni, they agreed to be available for the Camoni members and patients everyday of the year.<br />As a part of their contribution to the community of Camoni, the network's experts publish news and articles in the areas of their expertise - some of which might become main parts of the discussions throughout the Camoni blogs and forums .<br /><br />One of the notions for our public health cure is, that prevention (<a href="http://www.ncbi.nlm.nih.gov/pubmed/19667296?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">7</a>) is an ultimate key to ease many chronic conditions, such as diabetes, obesity, heart ailments and more. As sociability (<a href="http://www.scientificamerican.com/article.cfm?id=the-social-cure">8</a>) is a strong tool we try to approach it in many ways. In the net via forums, blogs, webmail, discussion groups, virtual meeting support groups etc. But also outside the net via familiar routes to the non-internet patient, these routes like music (<a href="http://mmd.sagepub.com/cgi/content/abstract/1/1/70">9</a>), art or social connections (<a href="http://www.ncbi.nlm.nih.gov/pubmed/19307557?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">10</a>) will be recorded in the Camoni website and slowly will be used to enable non-surfers to get familiar with the net.<br />Camoni aims to constantly evolve, improve and offer its users the newest communication tools for social networking in order to create a friendly and most useful virtual health environment.<br /><br />Until recently, it was recommended that in order to be healthy, one needs to exercise and to eat vegetables. Today one needs also to surf (<a href="http://www.forbes.com/2008/08/25/healthy-web-sites-tech-personal-cx_wt_0825health_slide.html?partner=email">11</a>).Dina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.com1tag:blogger.com,1999:blog-6207532470429889816.post-42832392203610071332009-03-25T07:22:00.000-07:002009-10-13T21:44:12.423-07:00Does NO metabolism play a role in the effects of vegetables in health?<strong>Nitric oxide formation via the reduction of nitrites and nitrates.<br /></strong>Ralt, D.<br /><span style="font-size:85%;">The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel<br /></span><a href="http://www.ncbi.nlm.nih.gov/pubmed/19477603?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum"><strong>Medical Hypotheses</strong></a><strong>,</strong> 2009, 73(5), 794-796<br /><br /><strong>Abstract</strong><br />A recent attribution of vegetables to human health stems from their effect on the gasotransmitter nitric oxide (NO). This commentary proposes that a major reason for this attribution is that vegetables are rich in nitrates. Recent research has shown that nitrites and nitrates are not only inert end-products of NO oxidation. In addition, they can be recycled back to bioactive NO and this pathway is an important alternative to the classical L-arginine-NO-synthase pathway.<br />Various chronic ailments, e.g. diabetes, obesity, high blood pressure, are symptomatic of NO bioavailability. Because NO deficiency is metabolically complex, natural nitrate-rich nutrients, such as green leafy vegetables, can improve these chronic ailments via the alternative nitrate-NO pathway.<br />This commentary implies an added value for vegetables in enhancing health such as cardiac health and in lowering the risks of maladies such as diabetes.<br /><br /><strong>Introduction</strong><br />Fruit and vegetables rich diets has been associated with lower risk of chronic diseases including cancer and cardiovascular disease and provide beneficial effects that can be attributed to a variety of protective agents [<a href="http://www.ncbi.nlm.nih.gov/pubmed/17704021?ordinalpos=81&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">1</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/18936332?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">2</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/18390796?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">3</a>]. In this commentary, the therapeutic attributes of vegetables will be discussed mainly in terms of their nitrates and nitrites content as a source for nitric oxide (NO) [<a href="http://www.ncbi.nlm.nih.gov/pubmed/12705354?dopt=AbstractPlus">4</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/18656681?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">5</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/18723086?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">6</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/18250359?ordinalpos=30&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">7</a>].<br />The past decade has witnessed a significant increase in the interest of biologists in NO. This highly reactive free radical, first considered only a noxious air pollutant, plays a vital role in many biological events including regulation of blood flow, immunity and neurotransmission [<a href="http://www.ncbi.nlm.nih.gov/pubmed/9769702?dopt=Abstract">8</a>].<br />Recent data demonstrate that NO is not only a paracrine substance. It has been shown that enzymatic generation of NO in the heart is capable of modulating remote physiological actions and cell signaling [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18685092?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">9</a>]. NO was also shown to affect the computational ability of the brain; it regulates information transmission across neurons [<a href="http://www.cell.com/neuron/abstract/S0896-6273(08)00758-7">10</a>]. Extensive data from studies on NO signals, on relaxation/stress processes and on health, supports a view of an NO net, serving as a body coordinator [<a href="http://www.ncbi.nlm.nih.gov/pubmed/17573200?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">11</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/19128825?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">12</a>].<br /><br />The necessity of NO for body functions is suggested by the fact that its deficiency is correlated with various chronic ailments such as, obesity [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18197180?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">13</a>], diabetes [<a href="http://www.ncbi.nlm.nih.gov/pubmed/19019231?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">14</a>], hypertension [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18685064?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">15</a>], pulmonary hypertension [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18991648?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">16</a>], osteoporosis [<a href="http://www.ncbi.nlm.nih.gov/pubmed/19006476?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">17</a>] and old age [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18347836?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">18</a>]. Supplementing NO levels is helpful and thus 5-phosphodiesterase inhibitors (e.g. Viagra), have a potential protective role in chronic ailments as coronary artery disease [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18498958?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=1&log$=relatedarticles&logdbfrom=pubmed">19</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/19127022?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">20</a>]. It is also not surprising that though helpful, the response rate to NO related drugs as Viagra is lower in diabetics [<a href="http://www.ncbi.nlm.nih.gov/pubmed/17539751?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">21</a>].<br /><br />The problematic nature of chronic ailments is the occurrence of an extended, not necessarily hazardous, condition (see the following elaboration on obesity). Thus, while temporary deficiency of NO may not pose a dramatic risk, a long term NO deficiency becomes hazardous.<br />NO bioavailability in the body depends on the rate of its synthesis and metabolism. Though arginine is a main precursor for the NO synthesis [<a href="http://www.ncbi.nlm.nih.gov/pubmed/16825696?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=4&log$=relatedarticles&logdbfrom=pubmed">22</a>], it has lately been established that mammalian nitrate and nitrite reduction can also contribute to NO biogenesis [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18167491?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">23</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/18992252?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">24</a>]. This commentary recommends an increase in consumption of nitrate-rich vegetables to prevent NO shortage and its consequential ailments. These nitrate-rich nutrients support health via reduction of nitrites and nitrates to NO [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18516050?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">25</a>]. Though beyond the scope of this commentary, it is worth mentioning that vegetable consumption has many nutritional benefits, these include supplementing precursors not only to NO but also to other gasotransmitters such as H2S [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18806820?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">26</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/18937169?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">27</a>].<br /><br /><strong>Discussion</strong><br />This section is composed of 3 parts:<br />- Description of a chronic ailment (obesity) and its NO deficiency.<br />- Curing NO shortage via nitrates and nitrites supplementation.<br />- Nitrate rich vegetables indeed improve chronic ailments.<br /><br />Obesity and NO deficiency<br />Obesity, which begins as simple overweight, over time becomes a malady correlated with ailments such as heart disease and diabetes [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18838723?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">28</a>]. NO deficiency may explain this pattern [<a href="http://www.ncbi.nlm.nih.gov/pubmed/17876034?ordinalpos=17&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">29</a>]. There are a number of studies that support this idea.<br />First, NO and citrulline are decreased in obese juveniles when compared to normal weight juveniles, and are negatively correlated with body weight. Arginine (the NO precursor) however, is increased in obese juveniles and is positively correlated with body weight [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18197180?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">13</a>]. Therefore, whereas low levels of NO are correlated with obesity,<br />it is not the lack of arginine that limits NO bioavailability.<br />Second, another study demonstrated that excess of fat in the body results in excess of the leptin hormone, which in turn, can lower the levels of bioavailable NO [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18689498?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">30</a>].<br />In addition, it is interesting to note that caloric restriction, without malnutrition, extends life span in a range of organisms [<a href="http://www.ncbi.nlm.nih.gov/pubmed/17341128?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">31</a>] and that there is an NO link between caloric restriction and mitochondria [<a href="http://www.ncbi.nlm.nih.gov/pubmed/16370369?ordinalpos=24&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">32</a>].<br /><br />Until the last century, obesity was a rare and impermanent condition and a transient lowered NO communication capacity was not necessarily unhealthy. Today, when obesity is mostly irreversible, prolonged inhibited NO bioavailability is hazardous and can account for the numerous maladies associated with obesity [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18838723?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">28</a>].<br /><br />The reduction of nitrites and nitrates<br />Increasing the sources of NO, may therefore, contribute to the health of the obese even in the absence of losing weight. When arginine oxidation to NO is prohibited, alternative routes for NO production are effective - the reduction of nitrites and nitrates [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18427145?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">33</a>].<br />Nitrate and nitrite are important alternative sources of NO in especially, but not exclusively, hypoxic states [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18835812?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">34</a>]. Following are some examples; The intermittent hypoxia improved glucose tolerance [<a href="http://www.ncbi.nlm.nih.gov/pubmed/15591781?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">35</a>]. Nitrite therapy augments ischemia-induced angiogenesis [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18508974?ordinalpos=30&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">36</a>], nitrate reduction is emerging as a regulator of physiological functions and tissue responses to myocardial infarction or stroke [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18167491?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">23</a>] and brief elevations in plasma nitrite trigger a concerted cardioprotective response [<a href="http://www.ncbi.nlm.nih.gov/pubmed/19229060?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">37</a>]. In addition to supplementation of NO compounds in acute situations, it is also effective in improving the urogenital system and skeletal health [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18627331?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">38</a>].<br />As suggested by Tamaki [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18753302?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">39</a>], dietary nitrite-derived NO generation may serve as a backup system when the NO synthase/L-arginine-dependent NO generation system is compromised.<br /><br />Best Nitrite and Nitrate Food Sources<br />Some of the best nitrate-rich foods are lettuce, spinach, beetroot [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18723086?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">6</a>] and fruits such as pomegranates [<a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17553710&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">40</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/18660860?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">41</a>]. Accumulating data shows that these foods improve various chronic ailments. Following are some examples; Beetroot reduces high blood pressure [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18250365?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">42</a>], green leafy vegetable consumption is linked to lower risk for diabetes in women [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18390796?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">3</a>], nitrate rich vegetables were shown to decrease the oxygen demand during exercise [<a href="http://www.ncbi.nlm.nih.gov/pubmed/17635415?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">43</a>], pomegranate juice consumption by patients with carotid artery stenosis decreases carotid IMT and systolic blood pressure [<a href="http://www.ncbi.nlm.nih.gov/pubmed/15158307?ordinalpos=64&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">44</a>] and indeed NO produced from nitrite plays important roles in limiting post-ischemic tissue injury [<a href="http://www.ncbi.nlm.nih.gov/pubmed/18940177?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">45</a>].<br />Because increasing substantially the daily consumption of vegetables is not simple [<a href="http://www.ncbi.nlm.nih.gov/pubmed/19053939?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">46</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/19014571?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">47</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/17383556?ordinalpos=17&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">48</a>], it seems worthwhile to spread the trend of drinking vegetable juices [<a href="http://www.eurekalert.org/pub_releases/2008-10/wsw-nss102308.php">49</a>] when dealing with chronic ailments.<br /><br />It is interesting to note that the Dunhuang scrolls dating to approximately 800 AD, suggested that nitrite and nitrate were used by the Chinese to relieve chest pain and reduce cold in the hands [<a href="http://www.ncbi.nlm.nih.gov/pubmed/16408064?ordinalpos=65&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">50</a>].<br /><br /><strong>Conclusions<br /></strong>Regulation of NO function is showing itself to be a complex event that maladies are associated with its disruption.<br />Here, it is proposed that vegetables can at least partly, reverse these effects by increasing NO generation via nitrate and nitrite. 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Dumbrell S, Mathai D: Getting young men to eat more fruit and vegetables: a qualitative investigation. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19053939?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">Health Promot J Austr 2008, 19:216-221. </a><br />47. van Sluijs EM, Skidmore PM, Mwanza K, Jones AP, Callaghan AM, Ekelund U, Harrison F, Harvey I, Panter J, Wareham NJ, Cassidy A, Griffin SJ: Physical activity and dietary behaviour in a population-based sample of British 10-year old children: the SPEEDY study (Sport, Physical activity and Eating behaviour: Environmental Determinants in Young people).<br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/19014571?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">BMC Public Health 2008, 8:388.<br /></a>48. Casagrande SS, Wang Y, Anderson C, Gary TL: Have Americans increased their fruit and vegetable intake? The trends between 1988 and 2002. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17383556?ordinalpos=17&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">Am J Prev Med. 2007, 32:257-263.<br /></a>49. Keen C: Vegetable juice is an effective and acceptable way to meet DASH vegetable recommendations. In American Dietetic Association Food & Nutrition conference, 25-28 October 2008, Chicago.<br /><a href="http://www.eurekalert.org/pub_releases/2008-10/wsw-nss102308.php">http://www.eurekalert.org/pub_releases/2008-10/wsw-nss102308.php</a><br />50. Gladwin MT, Schechter AN, Kim-Shapiro DB, Patel RP, Hogg N, Shiva S, Cannon RO 3rd, Kelm M, Wink DA, Espey MG, Oldfield EH, Pluta RM, Freeman BA, Lancaster JR Jr, Feelisch M, Lundberg JO: The emerging biology of the nitrite anion. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16408064?ordinalpos=65&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">Nat Chem Biol 2005, 1:308-314.</a><br /><br /><strong>- after publication relevant articles:</strong><br />* Food sources of nitrates and nitrites: the physiologic context for potential health benefits<br /><a href="http://www.ajcn.org/cgi/content/abstract/90/1/1?etoc">Am J Clin Nutr. 2009, 90(1), 1-10</a><br />* The University of Leicester team believe nitric oxide may change the way we think and hear.<br /><a href="http://news.bbc.co.uk/2/hi/health/8116194.stm">http://news.bbc.co.uk/2/hi/health/8116194.stm</a><br />Nitroglycerin Bioactivation<br /><a href="http://www.jbc.org/cgi/content/abstract/284/30/19878">http://www.jbc.org/cgi/content/abstract/284/30/19878</a><br /><a href="http://www.sciencedaily.com/releases/2009/08/090819125042.htm">http://www.sciencedaily.com/releases/2009/08/090819125042.htm</a>Dina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.com4tag:blogger.com,1999:blog-6207532470429889816.post-69846979582933571592008-07-05T12:34:00.000-07:002011-10-28T11:38:25.381-07:00A novel obese therapy - reversed (reduced) NO productionThe two major topics that attract my scientific interest are <a href="http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=17112">obesity</a> and the <a href="http://www.notes.co.il/dina/32099.asp">routes of NO </a>-nitric oxide (the above links summarise my previous studies).<br />NO, as I have suggested, enabled the initial physiological <a href="http://nettingno.blogspot.com/2008/01/was-nitric-oxide-archaic-communication.html">communication of multicellular organisms</a> and serves now as a support communication system in all living organisms.<br />It was thus no wonder for me to read the recent <a href="http://www.nature.com/ijo/journal/v32/n5/abs/0803795a.html">Austrian study</a>, which showed that obesity reduces the bioavailability of NO. The studied obese juveniles revealed highly significant alterations in the NO pathway. NOX and citrulline were decreased in obese compared to normal weight juveniles and negatively correlated with body weight. Arginine was increased in obese juveniles and positively correlated with body weight. Is the arginine accumulation related to the <a href="http://www.pnas.org/content/100/8/4843.abstract">arginine paradox</a>? Or mainly to the inhibition of NOX synthesis?<br /><a href="http://www.nature.com/ijo/journal/v32/n5/abs/0803795a.html" target="_blank">Int J Obes 2008 32: 826-831</a><br />I would like to suggest that the decrease in NO bioavailability in the obese (as well as in diabetics or others) is the result of a <a href="http://www.psychologicalscience.org/observer/getArticle.cfm?id=2317">“savings” strategy</a>…Resources are directed from activeness to accumulation (fat) and lowering the “primordial” communication system may be associated with this lower physiological tempo.<br />This might remind also aging… and indeed <a href="http://www.ncbi.nlm.nih.gov/pubmed/18347836?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">aging is also associated with an impaired </a>bioactivity of NO. It is no wonder that <a href="http://www.newscientist.com/article/dn14253-wine-chemical-improves-health-but-not-longevity-.html">obesity and aging have a lot in common</a>… See also <a href="http://www.ncbi.nlm.nih.gov/pubmed/15711582?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">the effect of adipose tissue</a> reduction on lifespan.<br /><br />This article is meant to point <strong>a fault in the obesity strategy </strong>(e.g., see below how smart is the Sirt1 startegy). It is true that the obese are trying to accumulate a reservoir for the future, but is it essential that they also lower the NO communication system?<br />I would try to explain such an evolutionary logic by suggesting that obesity was in the past (before our century) rare and impermanent and maybe a transient lowered communication capacity was even helpful…<br />Today when obesity is permanent, such prolonged inhibited communication is hazardous and might be the reason for the numerous maladies associated with obesity.<br />We could thus assume that enhancement of the NO resources might contribute to the health of the fat person even when they do not lose weight.<br />This reminds me of the <a href="http://www.technologyreview.com/Biotech/17704">resveratrol</a>, found in red wine, which keeps obese mice healthy, and of course the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001759">SirT1</a> which regulates energy metabolism and responds to caloric restriction in mice. It does so smartly, by <a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16366736">repressing UCP2 </a>, or via <a href="http://www.ncbi.nlm.nih.gov/pubmed/15175761?ordinalpos=59&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">promoting fat mobilization </a>...see also the recent PNAS <a href="http://www.pnas.org/content/early/2008/07/02/0802917105.abstract">Sirt1 article</a>... as well as the <a href="http://www.eurekalert.org/pub_releases/2008-07/uoc--crl072208.php">new data </a>on the essential CLOCK protein that regulates the body's circadian rhythms and works in balance with the Sirt1...<br />Is NO <a href="http://www.ncbi.nlm.nih.gov/pubmed/17991439?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">signaling in the biological clock</a>, impaired in the obese?<br /><a href="http://www.nature.com/ijo/journal/v32/n8/abs/ijo200878a.html">Recent data form Denmark </a>indeed show that human adipose tissue contains Sirt1 and the expression of Sirt1 can be regulated by calorie restriction just as in other species. Interesting... lean women had more than twofold higher Sirt1 expression in subcutaneous adipose tissue compared to obese women...Is this <a href="http://www.ncbi.nlm.nih.gov/pubmed/16370369?ordinalpos=24&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">related to NO</a>?<br /><br />So what can we do to improve wellness in spite of obesity? or in other words, how can we improve the NO availability?<br /><a href="http://ajpendo.physiology.org/cgi/content/full/291/5/E906">L-arginine supplementation</a> does indeed improve insulin sensitivity and endothelial function in obese type 2 diabetic patients…However I want to mention that it was associated with higher <a href="http://jama.ama-assn.org/cgi/content/full/295/1/58">postinfarction mortality</a>… and moreover, arginine was anyway increased in obese juveniles...<br /><br />I would like to suggest a<strong> novel wellness therapy</strong>; induction of the reverse route - NO formation via nitrites and nitrates… or maybe <a href="http://agnews.tamu.edu/showstory.php?id=554">through citrulline </a>who is also decreased with obesity.<br /><br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/18167491?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">Nitrate and nitrite</a> are important alternative source of NO to the classical L-arginine-NO-synthase pathway, in particular (but not only) under hypoxic states.<br />Note that <a href="http://www.springerlink.com/content/y1w2287v66357v54/">intermittent hypoxia indeed improved </a>glucose tolerance… nitrite therapy indeed <a href="http://www.pnas.org/content/105/21/7540.abstract">augments ischemia-induced angiogenesis</a>... and a role for <a href="http://www.ncbi.nlm.nih.gov/pubmed/18516050?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">mammalian nitrate reduction </a>in regulation of nitrite and NO homeostasis as well as: <a href="http://www.ncbi.nlm.nih.gov/pubmed/8557060?ordinalpos=76&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">Human endothelial cells bioactivate organic nitrates to nitric oxide</a>.<br />Hypoxia can also assist wellness via preventing the <a href="http://www.eurekalert.org/pub_releases/2008-05/sfeb-hts052308.php">producion of the toxic peroxynitrite</a>...<br />It is interesting to note that documents (<a href="http://idp.bl.uk/">Dunhuang scrolls</a>) dating to approximately 800 AD, suggested that <a href="http://www.ncbi.nlm.nih.gov/pubmed/16408064?ordinalpos=65&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">nitrite and nitrate were used by the Chinese </a>to relieve heart pains and cold in the hands.<br />I am a cautious person and thus I tend to recommend mainly wise nutrition (rather than food additives) and physical activity... please also consult your physician before applying any measure.<br />It is rather obvious that we should recommend <a href="http://www.eurekalert.org/pub_releases/2008-05/uu-niv050708.php">nitrate-rich vegetables </a>such as spinach, lettuce, radishes or beetroot or fruits like <a href="http://www.ncbi.nlm.nih.gov/pubmed/17553710?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">pomegranate</a>.<br />Nitrate rich vegeatbles such as <a href="http://www.ncbi.nlm.nih.gov/pubmed/18250365?ordinalpos=29&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">beetroot indeed reduces blood pressure</a> ... in another experiment it was shown that green leafy <a href="http://www.ncbi.nlm.nih.gov/pubmed/18390796?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">vegetable consumption was linked </a>to lower risk for diabetes in women and in another it was shown to decrease the oxygen <a href="http://www.ncbi.nlm.nih.gov/pubmed/17635415?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">demand during exercise</a>.<br />We could also <a href="http://www.ncbi.nlm.nih.gov/pubmed/17893036?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus">recommend Red wine</a>, which (besides its other qualities, such as <a href="http://www.webmd.com/food-recipes/news/20080626/red-wine-may-make-meat-meals-healthier?ecd=wnl_nal_071508">its antioxidants</a>) was shown to promote the reduction of nitrite to NO.<br />Small amounts of polyphenol-rich dark <a href="http://jama.ama-assn.org/cgi/content/full/298/1/49">chocolate improved formation of nitric </a>oxide.<br />On <a href="http://www.ncbi.nlm.nih.gov/pubmed/17891166?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">Viagra we could talk </a>as well, but <a href="http://nettingno.blogspot.com/2007/10/viagra-no-see-no-hear.html">please be moderate</a>…<br /><br />As for physical activity, a rather hypoxic is the body building…I wonder if my usual recommendation for body building (<a href="http://www.nature.com/ijo/journal/v32/n6/abs/ijo20085a.html">obesity</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/18468933?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">diabetes</a> or <a href="http://www.plosone.org/article/fetchArticle.action?articleURI=info:doi/10.1371/journal.pone.0000465">old age</a>) contributes to this reverse NO formation as well and thus makes this type of physical activity a major contributor to wellness.Dina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.com5tag:blogger.com,1999:blog-6207532470429889816.post-26095715521438512102008-03-17T09:58:00.000-07:002013-04-19T23:52:07.236-07:00Two urges to eat<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjFUySvpIxxOTwogeGFjY3S_3LurYbHmd_8_6nxz62xk9rrBf69VMciebIWE_sdv4HGjRWtPUtsUgD2vOlqF-P55f4Cs2mY9DOQ-3StU2sKAkiYXJv5nfLDiEo7rq9MoEtqPUBi8PPCr9A/s1600-h/Shower.gif"><img alt="" border="0" id="BLOGGER_PHOTO_ID_5293251158396981730" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjFUySvpIxxOTwogeGFjY3S_3LurYbHmd_8_6nxz62xk9rrBf69VMciebIWE_sdv4HGjRWtPUtsUgD2vOlqF-P55f4Cs2mY9DOQ-3StU2sKAkiYXJv5nfLDiEo7rq9MoEtqPUBi8PPCr9A/s320/Shower.gif" style="cursor: hand; float: left; height: 199px; margin: 0px 10px 10px 0px; width: 233px;" /></a><br />
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As a biologist, in a lifetime attempt to lose weight, I have always wondered about the fascinating nature of eating. I will begin with a general overview on eating and later discuss our conscious part in it.<br />
To physically live, we need two major ingredients - food and breath. Comparing the utilization of these two assets seems different; the eating appears to be volitional while continuous breathing feels essential. However, more accurate observation reveals that they are in principle rather similar; both have a volitional aspect and an essential aspect. However, they differ in their proportions. If we decide to stop breathing it will take at most a few minutes before we are naturally forced to restart breathing. When we decide to stop eating it takes much longer before we finally eat, regardless of our decision. The evolutionary rationale for this type of behavior is easy to understand. Oxygen is almost always present in our surrounding air and it is unnecessary to develop oxygen reserves in our body, therefore we need to breath continuously. Food on the other hand has not always been available, making it crucial to develop fat reserves and making it unnecessary to eat all the time.<br />
It is interesting to watch dolphins who, like us, breathe air but live in the sea where air is not available. They manage air more like we manage food, dolphins decide when to breath and they can also hold their <a href="http://www.kidscruz.com/DOL_BS.HTM">breath for long periods of time</a>.<br />
It is no wonder that dolphin <a href="http://www.sivananda.org/teachings/asana/headstnd.html">models are useful in yoga</a>, as yoga is based greatly on breathing.<br />
It is not coincidental that I have introduced <a href="http://www.americanheart.org/presenter.jhtml?identifier=3038035">yoga here</a>. Evolution has led us to develop both eating and breathing with major autonomous (non-voluntary) regulators. It can therefore be concluded that if we wish to control our eating, we need to develop “yoga type” dexterities.<br />
This also explains why most <a href="http://www.annals.org/cgi/content/abstract/147/1/41?etoc">diets fail</a>, as well as <a href="http://www.bmj.com/cgi/content/abstract/335/7631/1194">diet pills usage </a>(after 2-3 years). Note that the mammalian energy interface (regulating our eating) is related to <a href="http://www.biomedcentral.com/1471-2156/9/4">about 25%</a> (in mice) of the genes, thus trying to skirt it is pointless. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17550956?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">Genes are associated with the lean </a>component of our body mass as well. The main issue is that obesity is a very complex disposition, e.g. a <a href="http://www.nature.com/nature/journal/v452/n7186/abs/nature06758.html">core network module </a>in humans and mice was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits.<br />
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I will clarify, how long term effects on our nutrition, requires taking into account the bodily holistic physiological goals as well as its intricacy. Furthermore, affecting these goals intelligently (e.g. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18220080?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">good night sleep</a> preferably <a href="http://www.ncbi.nlm.nih.gov/pubmed/18417025?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">without headaches</a>, or via <a href="http://www.biomedcentral.com/1471-2156/9/4">physical activity</a>, preferably <a href="http://www.ncbi.nlm.nih.gov/pubmed/17910985?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">with music</a>) can lead automatically to smart eating habits and weight loss, without too many struggles. <a href="http://www.pnas.org/cgi/content/abstract/0801981105v1">Overeating, rather than the obesity </a>it causes, is the trigger for developing metabolic syndrome.<br />
Note that these special efforts are essential only at our wealthy times, e.g. when Cuba was hit with serious food shortage and people had to walk or cycle wherever they needed to go, health was <a href="http://www.newscientist.com/article/mg19826513.700-economic-crises-can-have-health-benefits.html">drastically improved</a>...(today, <a href="http://www.medpagetoday.com/PrimaryCare/Diabetes/38374" target="_blank">with better economics it is worse</a> again).<br />
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The major point I want to emphasize here is that the need to eat, as well as our satiety, are regulated by <b>two unrelated urges</b>. One is our daily energy expenditure and the other is the need to accumulate energy for the future (our bodily worry).<br />
Which urge we choose to fill, depends on our genetics and <a href="http://ann.sagepub.com/content/vol615/issue1/">condition</a>.<br />
If our body feels that there is no need to worry, we will be satiated once we eat approximately the averaged total energy that we expend daily. This was nicely demonstrated when healthy people were asked to drink various caloric shakes and they drank more or less to reach the same caloric total regardless of the shake.<br />
Recently, scientists from Chicago have demonstrated how the brain integrate information from multiple domains and <a href="http://www.ncbi.nlm.nih.gov/pubmed/18308706?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">assesses hunger or satiety</a>. We also have mechanisms to evaluate the caloric value of our foods. Scientists from Duke university have shown that calorie-rich nutrients can directly influence brain reward circuits that <a href="http://www.neuron.org/content/article/fulltext?uid=PIIS0896627308001190">control food intake independently of palatability </a>or functional taste transduction. Recently it was shown that the <a href="http://www.newscientist.com/article/dn13845-stomach-hormone-turns-hungry-people-into-junkies.html">ghrelin hormone can change </a>how we see and smell food, there is no doubt that multiple factors affect our satiety.<br />
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On the other hand, if our body feels “worried” (economically not emotionally), the second urge to eat will be initiated, an urge that will subside only when the worry disappears.<br />
Note the multiple reasons for this bodily worry (detailed later); if indeed a quarter of the genes are associated with our weight, it is no wonder that so many reasons are relevant.<br />
The obesity related second urge is manifested not only via the unending urge to eat, but also via <a href="http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=17112">bodily "saving policy</a>" [see the top sketch, no water (=calories) is wasted]. Is obesity <a href="http://www.ncbi.nlm.nih.gov/pubmed/19375759?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">associated with lower body temperatures</a>? </div>
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This obesity related policy prohibits dealing with health issues, <a href="http://www.psychologicalscience.org/observer/getArticle.cfm?id=2317">promotes no-exercise </a>and leads as much energy as possible to the fat storage. It naturally explains why obesity is associated with so many maladies (e.g. The stress cytokine <a href="http://www.ncbi.nlm.nih.gov/pubmed/19056968?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">IL-6, induces obesity related insulin resistance</a>). At <a href="http://www.ncbi.nlm.nih.gov/pubmed/16339331?ordinalpos=62&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">old age this "saving policy"</a> is manifested via sarcopenia (loss of muscle mass) which is frequently associated with fat accumulation and varoius disorderly conditions (<a href="http://www.ncbi.nlm.nih.gov/pubmed/16849867?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=4&log$=relatedarticles&dbfrom=pubmed">via renin-angiotensin</a> system?).<br />
What was once a <a href="http://news.bbc.co.uk/2/hi/health/6768365.stm">smart temporary strategy </a>to overcome food deficiency, more recently has become a steady limiting strategy that causes the fat to <a href="http://www.fasebj.org/cgi/content/abstract/fj.07-100735v2">become fatter </a>and sicker. Even obese children find <a href="http://www.ajcn.org/cgi/content/abstract/87/5/1121?etoc">food more reinforcing </a>than do nonoverweight children.<br />
It is, therefore, easy to conclude why obese people can/want to consistently <a href="http://www.ncbi.nlm.nih.gov/pubmed/17557992?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">eat more</a>, why they <a href="http://www.ncbi.nlm.nih.gov/pubmed/17822753?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">eat quickly</a> (to eat more per time), why <a href="http://www.eurekalert.org/pub_releases/2009-06/l-prm060909.php">satiation is impaired</a>, why they stop eating only <a href="http://www.bmj.com/cgi/content/abstract/337/oct21_2/a2002">when they are full</a>, why they eat <a href="http://mednews.wustl.edu/news/page/normal/11972.html">more on weekends</a> or when served with <a href="http://www.newscientist.com/article/mg19926634.500-dietsized-snack-packs-turn-off-willpower.html">smaller bags of potato chips</a> , why they behave <a href="http://www.eurekalert.org/pub_releases/2008-10/cfb-odc100308.php">differently at buffets</a>, why they stop eating due to technical reasons (e.g. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18198299?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">no food left on the table</a>), why there is <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16953260&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">no relationship between eating pattern and sensations of hunger </a>or fullness and thus why recommending healthy eating is usually futile.<br />
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<b>A note for the non-obese reader</b> - It will be difficult for the non-obese to empathize with the obesity behaviors as he is mainly acquainted with the first eating urge. It is not a problem for the non-obese to meet his energy needs and thus to follow <a href="http://www.sciencedaily.com/releases/2008/03/080301214753.htm">healthy nutrition guidelines </a>. The obese, in comparison, is eating due to the second urge and thus is rarely satiated or filling his energy needs as most energy is reffered to storage. For a laugh (and to better understand) see this "<a href="http://www.youtube.com/watch?v=qSbpyxFC24k&feature=related">getting fat</a>" youtube.<br />
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<b>Some of the reasons for bodily worry</b> (besides the trivial reason of lack of food):<br />
* Lack of physical activity (or muscles...) - it raises the question of why didn’t we move (not enough energy?) and possibly assumes that eating might supplement the energy required for movements. Note that <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=9778093&ordinalpos=17&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">exercising reduces the urge to eat</a>... or <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=14574343&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">also</a> another study from Scotland...as well as affects our <a href="http://www.pnas.org/content/early/2008/10/17/0808889105.abstract?etoc">mitochondrial coupling</a>. Indeed <a href="http://www.bmj.com/cgi/content/abstract/337/jul01_2/a439?papetoc">muscular strength is inversely</a> and independently associated with death in men.<br />
* Overeating - Digestion of the eaten food, requires abundance of efforts. Thus overeating will cause temporary lack of attention from most other bodily functions (we might feel tired). This evolutionary smart mechanism that was ideal when dealing with sporadic food abundance, is hazardous today when <a href="http://www.nature.com/ijo/journal/v32/n3/abs/0803737a.html">food abundance is constant</a>. It also may explains why <a href="http://www.technologyreview.com/Biotech/19413/">fasting is healthy</a>; all the digestive effort can be forwarded to other essential functions. This btw gives a sense of abundance and I will speculate and suggest that thus it does not promote bodily worry. It is no wonder that fasting has become a "hot" issue, e.g. Fasting-Induced Hormone <a href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7MFH-4SVCR05-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3aa56877c8133f3d669fe8fad438db88">FGF21</a>. Note that in contrast to fasting, <a href="http://news.bbc.co.uk/2/hi/health/6933686.stm">diet foods lead to obesity</a> as they promote its economic <a href="http://www.biomedcentral.com/1471-2431/6/33">Saving policy</a>. </div>
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See also how <a href="http://jn.nutrition.org/cgi/content/abstract/jn.108.100313v1">energy restriction induces extension of life </a>span in obese but not in lean mice.<br />
* "Thinner" fat cells metabolism (results of diets). Fat cells that have lost their stored fat, induce “<a href="http://www.ncbi.nlm.nih.gov/pubmed/18279786?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">catch-up</a>” processes which <a href="http://jn.nutrition.org/cgi/content/abstract/138/5/856?etoc">promote the second urge </a>of eating. Note how <a href="http://www.florey.edu.au/about/news-and-events/news-single-item/scientists-discover-way-to-increase-metabolism-for-weight-loss/?cHash=c465cfc2b2">manipulating fat cells </a>can increase the body’s metabolism. Also known, visceral adipose tissue <a href="http://www.fasebj.org/cgi/content/abstract/fj.07-100735v2">promotes obesity</a>.<br />
* <a href="http://www.ncbi.nlm.nih.gov/pubmed/16933178?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">Stress</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/18266500?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">ADHD</a> (attention deficit hyperactivity disorder) and other psychological disturbances (e.g. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18291294?ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">depression</a>) are associated with obesity. Note that stress is a complex issue, I have tried to define "<a href="http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=17112">muscle/body worry</a>" vs. "<a href="http://www.ncbi.nlm.nih.gov/pubmed/18155095?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">emotional worry</a>" as different stress "shippers" and to which we do not respond equally. e.g., “muscle/body worry” promotes eating while “emotional worry” represses eating.<br />
I propose to interpret the association between <a href="http://www.ncbi.nlm.nih.gov/pubmed/18155989?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">emotional stress and overeating </a>as a decreasing ability to control overeating and not as if the emotional-stress promotes overeating. Indeed, obesity (initial increased overeating) is associates with the emotional-stress over eating, while leanness is more likely to be associates with eating reluctance under stress.<br />
* Lack of sleep is also <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17974739&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">associated with obesity</a>... btw, <a href="http://news.bbc.co.uk/2/hi/uk_news/england/devon/4633787.stm">singing could help a silent night</a>...<br />
and not to mention (here, as the article is already too long...) <a href="http://www.eurekalert.org/pub_releases/2007-11/tu-ahr111307.php">lack of love </a>, <a href="http://www.eurekalert.org/pub_releases/2008-04/ori-bip042908.php">body image</a> or <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764526/?tool=pubmed">mind-body attitude</a>.</div>
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and of course other reasons that you might want to add…<br />
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<b>Final words</b><br />
Be smart if you wish to lose weight… rid yourself of your bodily worry ...<br />
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Don’t Muscle Worry, Be Happy. aps <a href="http://www.psychologicalscience.org/index.php/publications/observer/2008/april-08/dont-muscle-worry-be-happy.html" target="_blank">Observer, 21(4), April, 2008</a> </div>
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visit the CURE TOGETHER site:</div>
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<a href="http://www.curetogether.com/Obesity/">http://www.curetogether.com/Obesity/</a></div>
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Dina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.com12tag:blogger.com,1999:blog-6207532470429889816.post-39008300772632094212008-01-10T08:55:00.000-08:002009-08-20T21:29:00.918-07:00Is nitric oxide an archaic communication signal?Do you think of our primordial language? or, not even a language just an initial communication system…in those early days with groups of cells launching the transition from unicellular to multicellular organisms ~ a giga years ago…<br />Contemplating for a long time on the <a href="http://www.notes.co.il/dina/32099.asp">nitric oxide (NO) netting system</a>, has led me to suggest that maybe it was compounds like NO which enabled such initial communication. The advantage of a radical NO net as a communication tool is its simplicity and availability, and its drawback is its vulnerability and reactivity.<br />What triggered this blog was the study published by the <a href="http://www.paleo.geos.vt.edu/">Geobiology Research Group </a>of the Virginia Tech. They have discussed <a href="http://www.eurekalert.org/pub_releases/2008-01/vt-tee122007.php">the 2 explosive evolutionary events </a>which shaped the early history of multicellular life, and I thought whether it was gases like NO or CO which enabled the communication and organization of multicellularity. Such compounds are major signals at our times and they were even more predominant in the prehistoric days when life forms were simpler and less diverse.<br />The presence and functions of NO in the animal, vegetative or microbial kingdoms are <a href="http://www.pnas.org/cgi/content/full/96/25/14206">well documented.</a> In an <a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1187271#r46">historical review</a>, it was shown that NO is indeed an archaic molecule, biologically functioning in every living organism. It is not difficult to understand its abundance and essentiality, especially prior to the evolution of the biological nitrogen fixation. Nitrogen is an essential element for life and is often a limiting nutrient. As most nitrogen is locked in the stable form, N2, in the atmosphere, processes that can fix N2 into biologically available forms control the supply of nitrogen for organisms. On the early Earth, nitrogen is thought to have been fixed abiotically, as <a href="http://www.ncbi.nlm.nih.gov/pubmed/11452304">NO was formed during lightning discharge</a>.<br />In a <a href="http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/72/ec171?etoc">recent study, the functions of NO </a>in the developing circulatory system were expanded, NO is also important for vessel formation and tone.<br />While discussing these issues with Prof. Xiao from the Virginia Tech, he has suggested that the modern analogs for the early multicellular organisms would be <a href="http://www.ucmp.berkeley.edu/porifera/porifera.html">sponges</a> and <a href="http://www.ucmp.berkeley.edu/cnidaria/cnidaria.html">cnidarians</a>, and I guess it would be very illuminating to study the effects of NO on their social behavior. Any suggestions?<br />If indeed the NO net is so ancient, it was functioning before the evolution of the brain and senses. This opens a novel point of view for a current communication system, operating unrelated to emotions or mind, pls read the <a href="http://nettingno.blogspot.com/2007/10/viagra-no-see-no-hear.html">Viagra blog</a>. Is it part of what we attribute to alternative communication routes? mysticism? holism?<br /><br /><br />On nitric oxide signaling, metamorphosis, and the evolution of biphasic life cycles<br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/12950632?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedreviews&logdbfrom=pubmed">Evol Dev., 2003 Sep-Oct;5(5):542-50</a><br /><br />A hypothesis about cellular signaling with nitric oxide in the earliest life forms in evolution<br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/19439177?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">Free Radic Biol Med. 2009 May 9. </a>Dina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.com4tag:blogger.com,1999:blog-6207532470429889816.post-54509190884818342242007-10-22T06:51:00.000-07:002010-05-19T12:55:59.131-07:00Viagra - NO see, NO hearAfter discussing the <a href="http://www.jneuro-ophthalmology.com/pt/re/jneuroophth/abstract.00041327-200503000-00003.htm;jsessionid=HcRDvZF1Tz4ytDjrLzM125QRvrJTZxpDNvNjRmr7Gvgv2mhmw6yW!1899110359!181195628!8091!-1?index=1&database=ppvovft&results=1&count=10&searchid=1&nav=search">blindness risk</a>, the <a href="http://www.fda.gov/downloads/Drugs/DrugSafety/DrugSafetyNewsletter/ucm109169.pdf">FDA has decided to caution</a> from the potential risk of <a href="http://www.ncbi.nlm.nih.gov/pubmed/20479381">sudden hearing loss </a>and even <a href="http://www.webmd.com/erectile-dysfunction/news/20080530/amnesia-added-to-levitra-label">brief amnesia</a> associated with drugs like Cialis, Levitra, and Viagra. I would like to suggest a simple explanation to why do we prefer not to see or not to hear when we use those beneficiary drugs un-smartly.<br /><br />Recently I have <a href="http://shririm.com/2007/05/15/no-netting-health-and-stress/">published an article</a> suggesting that an intercellular communication network coordinates the various bodily functions. Radical gases like <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17882254&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum">nitric oxide (NO)</a> are signals in this net and its usability affects health and indicates wellness.<br /><br />From this netting point of view, stress is the sense of flow interruption or blockage of the information stream. Such flow interruption affects also physiological functions and can explain the association between stress and many ailments.<br />Data were presented to demonstrate that NO can be a potential stimulus in such nets and explain its multi-factorial role in health.<br />It was suggested that netting is a prerequisite route of wellness, enabling bodily autonomous managerial decisions.<br /><br />This vital diffusive NO network is extremely labile and potentially could contain the interplay of consciousness and unconsciousness. It may be effected by increasing the signals, e.g. via drugs like <a href="http://www.viagracures.com/news/">Viagra</a> or by reducing the noise via activities such as yoga or guided imagery<br /><br />Viagra can enhance the NO resultant cGMP by lowering its breakup rate and indeed was associated not only with better male sexuality but also with improved heart functions, urinary tract symptoms, pulmonary hypertension, jet leg and more…<br /><br />So where is the pitfall? Internal information crisis…<br /><br />As <a href="http://www.lindastone.net/">Linda Stone</a> stated we are facing wealth of opportunities, as we are not willing to give some of it up, we are in a permanent crisis.<br />Viagra indeed can help us in dealing with so much data, by increasing the signal over the noise. However, if we abuse its use by trying to process with it, more and more information, we could "bombard" our inner communication system which would collapse and with no other vent, would try to block further data entry. More is not necessarily better; even the cellular phone use, meant to improve family communication, <a href="http://www.blackwell-synergy.com/doi/abs/10.1111/j.1741-3737.2005.00213.x">is associated with increased family distress</a>.<br /><br />Our two major bodily data admission routes are seeing and hearing and these are the two reported dangers of Viagra - blindness and hearing loss. Ponder on what do we do when we are tired from our daily duties, we want to close our eyes in a quiet place...seeing and hearing... or even forget (transient amnesia)...<br /><br />What can be done? letting go...<br />I love to mention the Chinese philosopher Lau-Tsu, who wrote in The Tao te Ching, more than two thousands years ago, that the world is ruled by letting things take their course, and cannot be controlled through interference…Dina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.com2tag:blogger.com,1999:blog-6207532470429889816.post-7004148867992287882007-10-01T02:04:00.000-07:002007-10-01T02:15:22.212-07:00The Muscle-Fat DuelI have written an OpEd column for the Ivanhoe wellness channel, on my approach to the ever-widening obesity problem. Please read it, especially if you have any overweight children... and comment...<br /><a href="http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=17112">http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=17112</a>Dina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.com0tag:blogger.com,1999:blog-6207532470429889816.post-30075313178431254572007-04-26T09:11:00.000-07:002008-01-21T22:29:43.895-08:00Nitric oxide (NO) is everywhereThe past decade has witnessed an explosion in the interest of biologists in the gas nitric oxide (NO). This highly reactive free radical, first considered only a noxious air pollutant, is believed to play a vital role in many biological events including regulation of blood flow, immunity, and neurotransmission. Almost every cell and physiological parameter in our body is modulated by NO.<br /><br />A major issue of our times is the stress so common to our affluent society. Vast data from studies on NO signals, on relaxation/stress processes and on health, supports a novel look of an NO net serving as a coordinator in the body. Such coordination would be essential for health, and interference in it can be the root of stress. I have recently proposed that <a href="http://www.notes.co.il/dina/32099.asp">NO represents an alternative communication system </a>in the body and I am looking for NO "fans" to discuss current issues on this matter.<br /><br />Nobel Prize in Physiology or Medicine 1998<br /><a href="http://nobelprize.org/nobel_prizes/medicine/laureates/1998/illpres/">http://nobelprize.org/nobel_prizes/medicine/laureates/1998/illpres/</a><br /><br />The wellness solution<br /><a href="http://www.uthouston.edu/Media/newsreleases/nr2007/murad_book.html">http://www.uthouston.edu/Media/newsreleases/nr2007/murad_book.html</a>Dina Ralthttp://www.blogger.com/profile/15773736956050284255noreply@blogger.com0